rizin2ch

-->   Shibata Toshio Last modified date：2024.05.01 Assistant Professor / Department of Biology Faculty of Sciences 1 Research Interests 2 Academic Activities 2.1 Books 2.2 Papers 2.3 Reports 2.4 Presentations E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari. Homepage https://kyushu-u.elsevierpure.com/en/persons/toshio-shibata　Reseacher Profiling Tool　Kyushu University Pure Academic Degree Doctor of Philosophy Country of degree conferring institution (Overseas) No Field of Specialization Biochemistry, Innate immunity, Protein science ORCID(Open Researcher and Contributor ID) https://orcid.org/0000-0003-0211-5525 Total Priod of education and research career in the foreign country 00years00months Research Research Interests Unconventional protein secretion pathway mediated by fatty acylationkeyword : Myristoylation, Palmitoylation, Exosomes2015.04. Transglutaminase-catalyzed Crosslinking Suppresses Innate Immune Signaling in the Drosophila Gutkeyword : Transglutaminase, Drosophila, IMD pathway2011.04. Academic Activities Books  Show All Books >> 1. Shibata Toshio, Shun-ichiro Kawabata, Transglutaminases-Multiple Functional Modifiers and Targets for New Drug Discovery, Springer Japan, 2015.12, The existing knowledge of invertebrate transglutaminases with an emphasis on the importance of various physiological properties in innate immune reactions.. Reports  Show All Reports >> 1. Pluripotency and a secretion mechanism of Drosophila transglutaminaseTransglutaminase (TG) catalyses the formation of an isopeptide bond between glutamine and lysine residues and amine incorporation into specific glutamine residues. TG is conserved in all metazoans and functions both intracellularly and extracellularly. Here we review the existing knowledge of Drosophila TG with an emphasis on its pluripotency: Drosophila TG (i) plays a key role in cuticular morphogenesis, haemolymph coagulation, and entrapment against invading pathogens, (ii) suppresses the immune deficiency pathway to enable immune tolerance against commensal bacteria through the incorporation of polyamines into the nuclear factor-iB-like transcription factor Relish as well as through the protein-protein cross-linking of Relish, (iii) forms a physical matrix in the gut through cross-linking of chitin-binding proteins and (iv) is involved in the maintenance of homeostasis in microbiota in the gut. Moreover, we review the evidence that TG-A, one of alternative splicing-derived isoforms of Drosophila TG, is secreted through an endoplasmic reticulum/Golgi-independent pathway involving exosomes and fatty acylations.. Papers  Show All Papers >> 1. Toshio Shibata, Jinki Hadano, Daichi Kawasaki, Xiaoqing, Shun-ichiro Kawabata, Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations, The Journal of Biological Chemistry, 10.1074/jbc.M117.779710, 292, 25, 10723-10734, 2017.06. 2. Toshio Shibata, Kouki Maki, Jinki Hadano, Takumi Fujikawa, Kazuki Kitazaki, Takumi Koshiba, Shun-ichiro Kawabata, Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins, PLOS Pathogens, 10.1371/journal.ppat.1005244, 11, 10, e1005244, e1005244, 2015.10. 3. Toshio Shibata, Sanae Sekihara, Takumi Fujikawa, Ryuta Miyaji, Kouki Maki, Takeshi Ishihara, Takumi Koshiba, Shun-ichiro Kawabata, Transglutaminase-Catalyzed Protein-Protein Cross-Linking Suppresses the Activity of the NF-κB–Like Transcription Factor Relish, Science Signaling, 10.1126/scisignal.2003970, 6, 285, ra61, 2013.07. Presentations  Show All Presentations >> 1. 柴田 俊生, Transglutaminase-Catalyzed Protein-Protein Crosslinking Maintains the Gut Epithelial Immunity in Drosophila, The 55th Annual Drosophila Research Conference, 2014.03. Unauthorized reprint of the contents of this database is prohibited. Copyright © 2006, Kyushu University. All rights reserved.